Role of Sildenafil in ovulation induction A comparative study of outcomes with Sildenafil in ovulation induction cycles with Clomiphene Citrate

Background: Intraperitoneal instillations of local anaesthetic agents alone or in combination dexmedetomidine have been found to reduce post-operative pain following laparoscopic cholecystectomy. Aim: Comparing antinociceptive effects of intraperitoneal instillation of bupivacaine plain and bupivacaine with dexmedetomidine in patients undergoing laparoscopic cholecystectomy. Materials and methods: Study was conducted on 100 adult patients of ASA physical status 1 and 2 in the age group of 18 years to 60 years, posted for elective laparoscopic cholecystectomy under general anaesthesia. Patients were randomly divided on an alternate basis into two groups of 50 each. Group B: (n=50) patients received Intraperitoneal bupivacaine 50 ml 0.25% + 5 ml normal saline. Group DB: (n=50) Intraperitoneal bupivacaine 50 ml 0.25% + dexmedetomidine 1 μg/kg with normal saline 5 ml. Results: Mean pain scores were significantly lower in the group BD when compared to group B during the entire duration of the study. There was statistically significant difference in VAS pain score at 6, 8, 12, 18, 24 hours after surgery. Mean pain scores were significantly lower in the group BD Srinivas Rapolu, K Anil Kumar, Syed Ali Aasim. A comparative study on intraperitoneal bupivacaine alone or with dexmedetomidine for post-operative analgesia following laparoscopic cholecystectomy. IAIM, 2016; 3(12): 33-40. Page 34 when compared to group B during the entire duration of the study. There was statistically significant difference in VAS pain score at 6, 8, 12, 18, 24 hours after surgery. There was statistically significant difference between two groups of patients in terms of heart rate, systolic and diastolic blood pressure from 1 hour to 12 hours. 4 patients (8%) of group B and only 5 (10%) patients of groups B + D had postoperative nausea/vomiting, and 7 (14%) patients of group B and 2 (4%) patients of groups B+D had postoperative shoulder pain. Conclusion: Intraperitoneal instillation of dexmedetomidine with bupivacaine prolongs the duration of postoperative analgesia as compared to that with bupivacaine alone.

Evidence-based National Vaccine Policy.

India has over a century old tradition of development and production of vaccines. The Government rightly adopted self-sufficiency in vaccine production and self-reliance in vaccine technology as its policy objectives in 1986. However, in the absence of a full-fledged vaccine policy, there have been concerns related to demand and supply, manufacture vs. import, role of public and private sectors, choice of vaccines, new and combination vaccines, universal vs. selective vaccination, routine immunization vs. special drives, cost-benefit aspects, regulatory issues, logistics etc. The need for a comprehensive and evidence based vaccine policy that enables informed decisions on all these aspects from the public health point of view brought together doctors, scientists, policy analysts, lawyers and civil society representatives to formulate this policy paper for the consideration of the Government. This paper evolved out of the first ever ICMR-NISTADS national brainstorming workshop on vaccine policy held during 4-5 June, 2009 in New Delhi, and subsequent discussions over email for several weeks, before being adopted unanimously in the present form.

Evaluation of antioxidant potential of Clitoria ternata L. and Eclipta prostrata L.

Free radical-mediated oxidative stress is believed to be the primary cause of many disorders, such as cardiovascular diseases, brain dysfunction, cataract, diabetes mellitus, arthritis, cancer, ageing etc. In treatment of these diseases, antioxidant therapy has gained an utmost importance in the recent years. Current research is now directed towards finding naturally occurring antioxidants of plant origin. In Indian system of medicine, Clitoria ternata L. and Eclipta prostrata L. are the important medicinal plants, which have a wide range of applications. In the present study, the antioxidant potential of aqueous extracts of C. ternata and E. prostrata was evaluated by determining the levels of enzymatic and non-enzymatic antioxidants. In vitro antioxidant capacity was also determined using different assays and the results were compared with standard antioxidants such as butylated hydroxy toluene (BHT), ascorbic acid and rutin. Our results showed that both plant extracts possessed significant levels of enzymatic and non-enzymatic antioxidants and also exhibited antioxidant capacity. However, C. ternata showed higher levels of enzymatic and non-enzymatic antioxidants, as compared to E. prostrata. In addition, the antioxidant capacity of C. ternata was observed to be significant as compared to E. prostrata.